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Inhalt

Team

Principle Investigator

Preclinical 3D models of MDS and AML

Dr. sc. hum. Eva Altrock

Contact

Fields of expertise

  • Improvement of MDS modelling
  • 3D Ossicle model as an alternative method
  • 3D in vitro cell culture of MDS MSCs and HSPCs
  • (PhD student: cand. med. Ann-Christin Belzer)

Preclinical testing of novel therapeutic substances

Dr. sc. hum. Nanni Schmitt

Contact

Fields of expertise

  • Generation of MDS models to be used as pre-clinical platforms, and their further optimization
  • Pre-clinical assessment of NK cell based therapies for treatment of AML and high-risk MDS
  • PhD students: cand. med. Alexandra Beck, Teresa Klink und Meret Hahn

Investigations of the pathomechanism of myeloid neoplasms

Dr. sc. hum. Vladimir Riabov

M. sc. Alessa Klär

Alumni

Dr. med. Qingyu Xu

Contact

Fields of expertise

  • Role of MSC/HSC crosstalk in the pathogenesis of myeloid neoplasms (MDS and MPN), molecular studies (Vladimir Riabov and Alessa Klär) 
  • Generation of preclinical models to therapeutically target AML/immune cell crosstalk (Vladimir Riabov)
  • R-loops mediated replication stress as a novel therapeutic target in MDS with splicing factor mutations (Vladimir Riabov and MD student: Marie Demmerle)
  • Investigation of the role of BM microenvironment in MDS (Vladimir Riabov and Alessa Klär)

Contact

Fields of expertise

  • Role of MSC/HSC crosstalk in the pathogenesis of myeloid neoplasms (MDS and MPN), molecular studies (Vladimir Riabov and Alessa Klär) 
  • Investigation of the role of BM microenvironment in MDS (Vladimir Riabov and Alessa Klär)

Molecular analysis of myeloid neoplasms

Dr. med. Alexander Streuer

Contact

Fields of expertise

  • Next Generation Sequencing (RNA sequencing, whole exome sequencing, single-cell RNA sequencing)
  • Pipelines for the analysis of clonal alterations of leukemic cells
  • “Radiomics”- the role of spatial sampling for Contact: therapy decisions and outcome

Scientific Management/ Study Coordination

Dr. rer. med. Felicitas Rapp

Contact

Fields of expertise

  • Management of research projects
  • Administration of funding
  • Preparation of new clinical studies
  • Coordination of ongoing studies

Technicians

Verena Nowak

Iris Palme

Julia Obländer

Elena Speck

Nadine Weimer

(parental leave)

Contact

Phone + 49 621/383-71313
Fax +49 621/383-71329

Fields of expertise

  • Research projects
  • Clinical Routine: Cell culture, FACS, PCR
  • Biosampling

Clinical studies

  • Innovative novel therapies
  • Clinical studies for patients with myelodysplastic neoplasia or leukemia
  • Close interaction with scientists: “from bench to bedside”
  • Contact: Prof. Wolf-Karsten Hofmann