Veröffentlichungen

Outbreak of SARS-CoV-2 in a geriatric acute-care ward during summer 2023: current aspects of infection control in the postpandemic period. Lange B, Mesquita G, Burkhardt H, Gerigk M, Heininger A. GMS Hyg Infect Control. 2024 Jan 30;19: Doc02. doi: 10.3205/dgkh000457. eCollection 2024.

The Impact of Clinical Factors and SARS-CoV-2 Variants on Antibody Production in Vaccinated German Healthcare Professionals Infected Either with the Delta or the Omicron Variant. Gerhards C, Steingass M, Heininger A, Lange B, Hetjens M, Gerigk M, Neumaier M, Evliyaoglu O, Kittel M.  Vaccines (Basel). 2024 Feb 5;12(2):163. doi: 10.3390/vaccines12020163. PMID: 38400146; PMCID: PMC10893335.

The global burden of antimicrobial resistance - urinary tract infections. Von Vietinghoff S, Shevchuk O, Dobrindt U, Engel DR, Jorch SK, Kurts C, Miethke T, Wagenlehner F.  Nephrol Dial Transplant. 2024 Mar 27;39(4):581-588. doi: 10.1093/ndt/gfad233.

Molecular surveillance of carbapenem-resistant Enterobacterales in two nearby tertiary hospitals to identify regional spread of high-risk clones in Germany, 2019-2020.  Boutin S, Welker S, Gerigk M, Miethke T, Heeg K, Nurjadi D.  J Hosp Infect. 2024 Jul; 149:126-134. doi: 10.1016/j.jhin.2024.04.014. Epub 2024 May 7.

Rifampin-resistant periprosthetic joint infections are associated with worse functional outcome in both acute and chronic infection types. Baumgärtner T, Bdeir M, Dally FJ, Gravius S, Hai AAE, Assaf E, Hetjens S, Miethke T, Darwich A.  Diagn Microbiol Infect Dis. 2024 Oct;110(2):116447. doi: 1016/j.diagmicrobio.2024.116447. Epub 2024 Jul 19.

Potential role of Vitamin D in immune response in patients with viral Hepatitis. Gerhards C, Teufel A, Gerigk M, French M, Antoni C, Ebert M, Neumaier M, Evliyaoglu O.  Nutrition. 2024 Aug; 124:112447. doi: 10.1016/j.nut.2024.112447. Epub 2024 Mar 30.

Lightweight Visual Transformers Outperform Convolutional Neural Networks for Gram-Stained Image Classification: An Empirical Study. Kim HE, Maros ME, Miethke T, Kittel M, Siegel F, Ganslandt T.  Ganslandt T.Biomedicines. 2023 Apr 30;11(5):1333. doi: 10.3390/biomedicines11051333.

Therapy Guidance by Vaginal Smears of Pregnant Women With Preterm Complications in Correlation With Maternal and Neonatal Outcome: A Retrospective Analysis. Stefanovic S, Werner E, Gerigk M, Hornung R, Karic U, Wei C, Tuschy B, Berlit S, Sütterlin M.  In Vivo. 2023 May-Jun;37(3):1211-1218. doi: 10.21873/invivo.13169.

Bacterial Co- or Superinfection in Patients Treated in Intensive Care Unit with COVID-19- and Influenza-Associated Pneumonia. Schoettler JJ, Sandrio S, Boesing C, Bauer L, Miethke T, Thiel M, Krebs J. Pathogens. 2023 Jul 10;12(7):927. doi: 10.3390/pathogens12070927.

Rapid, adaptable and sensitive Cas13-based COVID-19 diagnostics using ADESSO. Casati B, Verdi JP, Hempelmann A, Kittel M, Klaebisch AG, Meister B, Welker S, Asthana S, Di Giorgio S, Boskovic P, Man KH, Schopp M, Ginno PA, Radlwimmer B, Stebbins CE, Miethke T, Papavasiliou FN, Pecori R.   Nat Commun. 2022 Jun 8;13(1):3308. doi: 10.1038/s41467-022-30862-y.

The Promoter of the Immune-Modulating Gene TIR-Containing Protein C of the Uropathogenic Escherichia coli Strain CFT073 Reacts to the Pathogen's Environment. Hemberger J, Ittensohn J, Griffiths H, Keller M, Costina V, Albrecht S, Miethke M.   Int J Mol Sci. 2022 Jan 20;23(3):1148 doi: 10.3390/ijms23031148.

Evaluation einer SARS-CoV-2-Teststrategie zu Beginn der COVID-19-Pandemie in einem südwestdeutschen Universitätsklinikum [Evaluation of a SARS-CoV-2 test strategy in a southwestern university hospital at the beginning of the COVID-19 pandemic]. Trimborn A, Gerigk M, Heininger A, Santhanam N, Walter T, Lange B.  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2021 Mar;64(3):353-359. German. doi: 10.1007/s00103-021-03287-z. Epub 2021 Feb 12.

TcpC inhibits toll-like receptor signaling pathway by serving as an E3 ubiquitin ligase that promotes degradation of myeloid differentiation factor 88. Fang JQ, Ou Q, Pan J, Fang J, Zhang DY, Qiu MQ, Li YQ, Wang XH, Yang XY, Chi Z, Gao W, Guo JP, Miethke T, Pan JP.  PLoS Pathog. 2021 Mar 31;17(3) e1009481. doi: 10.1371/journal.ppat.1009481. eCollection 2021 Mar.

Regulation of Expression of the TIR-Containing Protein C Gene of the Uropathogenic Escherichia coli Strain CFT073. Ittensohn J, Hemberger J, Griffiths H, Keller M, Albrecht S, Miethke T. Pathogens. 2021 May 1;10(5):549. doi: 10.3390/pathogens10050549.

Presence of gustatory and olfactory dysfunction in the time of the COVID-19 pandemic.  Kusnik A, Weiss C, Neubauer M, Huber B, Gerigk M, Miethke T, Hunter N, Rotter N, Ludwig S, Schell A, Ebert MP, Teufel A. BMC Infect Dis. 2021 Jun 26;21(1):612. doi: 10.1186/s12879-021-06294-2.

A 28-Day-Old Boy with Multifocal Osteomyelitis Mimicking Non-Accidental Injury. Papan C, Karremann M, Weis M, Petzold A, Zahn K, Schroten H, Weichert S, Tenenbaum T. A 28-Day-Old Boy with Multifocal Osteomyelitis Mimicking Non-Accidental Injury. Klin Padiatr. 2021 Mar;233(2):91-93. English. doi: 10.1055/a-1219-8053. Epub 2020 Aug 6.

Breakthrough Infections in BNT162b2-Vaccinated Health Care Workers. Lange B, Gerigk M, Tenenbaum T. N Engl J Med. 2021 Sep 16;385(12):1145-1146. doi: 10.1056/NEJMc2108076. Epub 2021 Aug 18.

Delayed Rifampin Administration in the Antibiotic Treatment of Periprosthetic Joint Infections Significantly Reduces the Emergence of Rifampin Resistance. Darwich A, Dally FJ, Bdeir M, Kehr K, Miethke T, Hetjens S, Gravius S, Assaf E, Mohs E.  Antibiotics (Basel). 2021 Sep 21;10(9):1139. doi: 10.3390/antibiotics10091139.

Co-Medication and Nutrition in Hepatocellular Carcinoma: Potentially Preventative Strategies in Hepatocellular Carcinoma. Kusnik A, Hunter N, Rasbach E, Miethke T, Reissfelder C, Ebert MP, Teufel A.  Dig Dis. 2021;39(5):526533.  doi: 10.1159/000514277. Epub 2021 Jan 11.

Deep Learning Frameworks for Rapid Gram Stain Image Data Interpretation: Protocol for a Retrospective Data Analysis. Kim H, Ganslandt T, Miethke T, Neumaier M, Kittel M. JMIR Research Protocols 2020 Jul 13; 9(7): e16843. doi: 10.2196/16843.

Emergence of carbapenem-resistant ST131 Escherichia coli carrying bla OXA-244 in Germany, 2019 to 2020. Welker S, Boutin S, Miethke T, Heeg K, Nurjadi D. Euro Surveillance 2020 Nov; 25(46):2001815. doi: 10.2807/1560-7917.ES.2020.25.46.2001815.

Thirty years of VRE in Germany - "expect the unexpected": The view from the National Reference Centre for Staphylococci and Enterococci. Werner G, Neumann B, Weber RE, Kresken M, Wendt C, Bender JK; VRE study group. Drug Resist Updat. 2020 Dec; 53:100732. doi: 10.1016/j.drup.2020.100732. Epub 2020 Oct 27.

Rapid susceptibility testing of multi-drug resistant Escherichia coli and Klebsiella by glucose metabolization monitoring. Kittel M, Findeisen P, Ghebremedhin B, Miethke T, Grundt A, Ahmad-Nejad P, Neumaier M. Clin Chem Lab Med. 2019 Jul 26;57(8):1271-1279 doi: 10.1515/cclm-2018-1178.

Infectious causes of   peripheral facial nerve palsy in children-a retrospective cohort study with long-term follow-up. Papan C, Kremp L, Weiß C, Petzold A, Schroten H, Tenenbaum T. Eur J Clin Microbiol Infect Dis. 2019 Nov;38(11):2177-2184. doi: 10.1007/s10096-019-03660-6. Epub 2019

Course of colonization by multidrug-resistant organisms after allogeneic hematopoietic cell transplantation.
Heidenreich D, Kreil S, Jawhar M, Müller N, Nolte F, Becker KP, Miethke T, Hofmann WK, Klein SA. Ann Hematol. 2018 Dec;97(12):2501-2508. doi: 10.1007/s00277-018-3475-6.

Direct MS-Based Bacterial Identification of Blood Cultures. Comparison of an In-House TritonX-Protocol with Bruker-Sepsityper?
Kittel M, Greulich A, Findeisen P, Haselmann V, Burrer A, Willem C, Miethke T, Ahmad-Nejad P, Neumaier M. Clin Lab. 2018 Oct 31;64(11). doi: 10.7754/Clin.Lab.2018.180522.

Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients.
Postina P, Skladny J, Boch T, Cornely OA, Hamprecht A, Rath PM, Steinmann J, Bader O, Miethke T, Dietz A, Merker N, Hofmann WK, Buchheidt D, Spiess B. Front Microbiol. 2018 Mar 27;9:555. doi: 10.3389/fmicb.2018.00555. eCollection 2018.

The inventory as a core element in the further development of the science curriculum in the Mannheim Reformed Curriculum of Medicine.
Eckel J, Schüttpelz-Brauns K, Miethke T, Rolletschek A, Fritz HM. GMS J Med Educ. 2017 May 15;34(2):Doc22. doi: 10.3205/zma001099. eCollection 2017.

Vaccination with the polymorphic membrane protein A reduces Chlamydia muridarum induced genital tract pathology. Müller T, Becker E, Stallmann S, Waldhuber A, Römmler-Dreher F, Albrecht S, Mohr F, Hegemann JH, Miethke T. Vaccine. 2017; 35:2801-2810.

Phosphotransferase systems in Enterococcus faecalis OG1RF enhance anti-stress capacity in vitro and in vivo.   Peng Z, Ehrmann MA, Waldhuber A, Niemeyer C, Miethke T, Frick JS, Xiong T, Vogel RF. Res Microbiol. 2017; doi: 10.1016/j.resmic.2017.03.003.

Immunity to uropathogens: the emerging roles of inflammasomes.Hamilton C, Tan L, Miethke T, Anand PK. Nat Rev Urol. 2017; 14:284-295.

Multidrug-resistant organisms in allogeneic hematopoietic cell transplantation. Heidenreich D, Kreil S, Nolte F, Hofmann WK, Miethke T, Klein SA. Eur J Haematol. 2017; 98:485-492

Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets.
Ambite I, Puthia M, Nagy K, Cafaro C, Nadeem A, Butler DS, Rydström G, Filenko NA, Wullt B, Miethke T, Svanborg C. PLoS Pathog. 2016; 12:e1005848.

Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation.
Waldhuber A, Puthia M, Wieser A, Cirl C, Dürr S, Neumann-Pfeifer S, Albrecht S, Römmler F, Müller T, Zheng Y, Schubert S, Groß O, Svanborg C, Miethke T.
J Clin Invest. 2016 Jul 1;126(7):2425-36. doi: 10.1172/JCI81916. Epub 2016 May 23.

A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.
Waldhuber A, Snyder GA, Römmler F, Cirl C, Müller T, Xiao TS, Svanborg C, Miethke T.
Pathogens. 2016 Feb 29;5(1). pii: E25. doi: 10.3390/pathogens5010025.

Direct comparison of galactomannan performance in concurrent serum and bronchoalveolar lavage samples in immunocompromised patients at risk for invasive pulmonary aspergillosis.
Boch T, Buchheidt D, Spiess B, Miethke T, Hofmann WK, Reinwald M.
Mycoses. 2016, 59:80-5.

Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells.
Römmler F, Hammel M, Waldhuber A, Müller T, Jurk M, Uhlmann E, Wagner H, Vollmer J, Miethke T.
PLoS One. 2015, 10:e0116703.

Rapid detection of cefotaxime-resistant Escherichia coli by LC-MS.Burrer A, Findeisen P, Jäger E, Ghebremedhin B, Grundt A, Ahmad-Nejad P, Miethke T, Neumaier M. Int J Med Microbiol. 2015, 305:860-4.

Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.
Snyder GA, Deredge D, Waldhuber A, Fresquez T, Wilkins DZ, Smith PT, Durr S, Cirl C, Jiang J, Jennings W, Luchetti T, Snyder N, Sundberg EJ, Wintrode P, Miethke T, Xiao TS.
J Biol Chem. 2014, 289:669-79. TM and TX are corresponding authors

Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB.
Través PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis EA, Martín-Sanz P, Palladino MA, Boscá L.
Chem Biol. 2014, 21:955-66.

Incidence of Cyp51 A key mutations in Aspergillus fumigatus-a study on primary clinical samples of immunocompromised patients in the period of 1995-2013.
Spiess B, Postina P, Reinwald M, Cornely OA, Hamprecht A, Hoenigl M, Lass-Flörl C, Rath PM, Steinmann J, Miethke T, Lauten M, Will S, Merker N, Hofmann WK, Buchheidt D.
PLoS One. 2014, 9:e103113.

Granzyme A produces bioactive IL-1β through a nonapoptotic inflammasome-independent pathwayHildebrand D, Bode KA, Rieß D, Cerny D, Waldhuber A, Römmler F, Strack J, Korten S, Orth JH, Miethke T, Heeg K, Kubatzky KF. Cell Rep. 2014, 9:910-7.

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.
Snyder G.A., C. Cirl, J. Jiang, K. Chen, A. Waldhuber, P. Smith, F. Römmler, N. Snyder, T. Fresquez, S. Dürr, N. Tjandra, T. Miethke and T.S. Xiao.
ProcNatlAcadSci U S A. 110:6985-90. 2013. TM and TX are corresponding authors.

Acute osteomyelitis of the humerus mimicking malignancy: Streptococcus pneumoniae as exceptional pathogen in an immunocompetent adult.
Prodinger, P. M., H. Pilge, I. J. Banke, D. Bürklein, R. Gradinger, T. Miethke, and B.M. Holzapfel.
BMC Infect Dis. 13:266, 2013.

Guanine-modification of inhibitory oligonucleotides potentiates their suppressive function.
Römmler, F., J. Jurk, E. Uhlmann, M. Hammel, A. Waldhuber, L. Pfeiffer, H. Wagner, J. Vollmer and T. Miethke.
J Immunol. 2013, 191:3240-53.

Rapid detection of ampicillin resistance in Escherichia coli by quantitative mass spectrometry.
Grundt, A., P. Findeisen, T. Miethke, E. Jäger, P. Ahmad-Nejad and M. Neumaier.
J. Clin. Microbiol. 50:1727-9, 2012

Candidiasis caused by Candida kefyr in a neonate: case report.
Weichert S, Reinshagen K, Zahn K, Geginat G, Dietz A, Kilian AK, Schroten H, Tenenbaum T.
BMC Infect Dis. 2012 Mar 18;12:61. doi: 10.1186/1471-2334-12-61.

Pseudomonas aeruginosa outbreak in a pediatric oncology care unit caused by an errant water jet into contaminated siphons.
Schneider H, Geginat G, Hogardt M, Kramer A, Dürken M, Schroten H, Tenenbaum T.
Pediatr Infect Dis J. 2012 Jun; 31(6): 648 - 50. doi: 10.1097 / INF. 0b013e31824d1a11

Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: identification by gas chromatography-tandem mass spectrometry and quantification by enzyme immunoassay.
Kupfahl C, Tsikas D, Niemann J, Geginat G, Hof H.
Mol Immunol. 2012 Jan;49(4):621-7. doi: 10.1016/j.molimm.2011.10.010. Epub 2011 Nov 25.

Linkage of bacterial protein synthesis and presentation of MHC class I-restricted Listeria monocytogenes-derived antigenic peptides.
Grauling-Halama S, Schenk S, Bubert A, Geginat G.
PLoS One. 2012;7(3):e33335. doi: 10.1371/journal.pone.0033335. Epub 2012 Mar 12.

Ultra late onset group B streptococcal sepsis with acute renal failure in a child with urethral obstruction: a case report.
Freudenstein D, Reinshagen K, Petzold A, Debus A, Schroten H, Tenenbaum T.
J Med Case Rep. 2012 Feb 20;6:68. doi: 10.1186/1752-1947-6-68.

Chemotaxis of T-cells after infection of human choroid plexus papilloma cells with Echovirus 30 in an in vitro model of the blood-cerebrospinal fluid barrier.
Schneider H, Weber CE, Schoeller J, Steinmann U, Borkowski J, Ishikawa H, Findeisen P, Adams O, Doerries R, Schwerk C, Schroten H, Tenenbaum T.
Virus Res. 2012 Dec;170(1-2):66-74. doi: 10.1016/j.virusres.2012.08.019. Epub 2012 Sep 19.

Toll Toll-like receptors 2 and 4 regulate the frequency of IFNγ-producing CD4+ T-cells during pulmonary infection with Chlamydia pneumoniae.
Wantia N., N. Rodriguez, C. Cirl, T. Ertl, S. Dürr, L.E. Layland, H. Wagner and T. Miethke.
PLoS One. 6:e26101, 2011.

Innate immunity in the male genital tract: Chlamydia trachomatis induces keratinocyte-derived chemokine production in prostate, seminal vesicle and epididymis/vas deferens primary cultures.
Mackern-Oberti, J.P., M. Maccioni, M. L. Breser, A. Eley, T. Miethke and V.E. Rivero.
J. Med. Microbiol.60:307-16, 2011.

Antibiotic prophylaxis in primary and revision hip arthroplasty: what is the evidence?
Gradl, G., C. Horn, L. K. Postl, T. Miethke and H.Gollwitzer.
Orthopade. 40:520-7, 2011.

Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45- cells.
Mackern-Oberti, J. P., M. L. Breser, N. Nuñez, M. Maccioni, N. Rodríguez, N. Wantia, T. Ertl, T. Miethke and V. E. Rivero.
Reproduction 142:427-37, 2011.

Gliotoxin as putative virulence factor and immunotherapeutic target in a cell culture model of cerebral aspergillosis.
Speth C, Kupfahl C, Pfaller K, Hagleitner M, Deutinger M, Würzner R, Mohsenipour I, Lass-Flörl C, Rambach G.
Mol Immunol. 2011 Sep;48(15-16):2122-9. doi: 10.1016/j.molimm.2011.07.005. Epub 2011 Jul 30