Publikationen 2025
- Zanella P, Loss I, Parlato R, Weishaupt JH, Sala C, Verpelli C, Boeckers TM, Catanese A
ALS mutations shift the isoelectric point of the KIF5A C-terminal inducing protein aggregation and TDP-43 mislocalization. J Neurosci; 2025 Jun 24; doi:10.1523/JNEUROSCI.1658-24.2025 - Kourtesakis A, Bailey E, Chow HNH, Rohdjeß H, Mussnig N, Agardy DA, Hoffmann DCF, Chih YC, Will R, Kaulen L, Hahn M, Wagener R, Reibold D, Pusch S, Sahm F, Sauer T, Schmitt M, Bunse L, Platten M, Wick W, Kessler T
Utilization of universal-targeting mSA2 CAR-T cells for the treatment of glioblastoma. Oncoimmunology; 2025 Dec; doi:10.1080/2162402X.2025.2518631 - Kirou RA, Pinal-Fernandez I, Casal-Dominguez M, Pak K, Ikenaga C, Nelke C, Wischnewski S, Del Orso S, Naz F, Islam S, Gutierrez-Cruz G, Lloyd TE, Schirmer L, Ruck T, Stenzel W, Selva-O'Callaghan A, Milisenda JC, Mammen AL
Activated Dendritic Cell Subsets Characterize Muscle of Inclusion Body Myositis Patients and Correlate with KLRG1+ and TBX21+ CD8+ T cells. medRxiv; 2025 Jun 5; doi:10.1101/2025.06.04.25328910 - Huang Y, Geywitz C, Bandaru A, Glass IA, Birth Defects Research Laboratory, Schirmer L, Nobuta H, Dreyfus C
The mGluR5 Agonist, CHPG, Enhances Numbers of Differentiated Human Oligodendrocytes. bioRxiv; 2025 May 31; doi:10.1101/2025.05.31.656838 - Polymeris AA, Koga M, Strbian D, Vedamurthy A, Krishnan M, Branca M, Horvath T, Goeldlin M, Shim G, Gumbinger C, Zhang L, Kristoffersen ES, Desfontaines P, Vanacker P, Alonso A, Poli S, Nunes AP, Caracciolo NG, Kneihsl M, Kahles T, Giudici D, Räty S, Tiainen M, Dawson J, Fischer U, ELAN Investigators
Antiplatelet Use Prior to Anticoagulant Initiation in Patients With Atrial Fibrillation-Related Ischemic Stroke: An ELAN Trial Analysis. J Stroke; 2025 May; doi:10.5853/jos.2024.04322 - Fastner C, Tavas E, Hetjens S, Kruska M, Ansari U, Behnes M, Kuschyk J, Duerschmied D, Burkhardt H, Alonso A, Akin I
Left atrial appendage occlusion in vulnerable oldest-old patients - Effectiveness and safety in a large single-center registry. J Neurol Sci; 2025 Jun 15; doi:10.1016/j.jns.2025.123521 - Sandikci V, Ebert A, Marzina A, Platten M, Szabo K, Hoyer C
Hippocampal contributions to semantic memory retrieval: Strategy-specific impairments in transient global amnesia. J Neuropsychol; 2025 May 2; doi:10.1111/jnp.12430 - Olazagoitia-Garmendia A, Rojas-Márquez H, Trobisch T, Moreno-Castro C, Rodriguez Etxebarria A, Mentxaka J, Tripathi A, Yang B, Martin Ruiz I, Anguita J, Meana JJ, Ding Y, Dutta R, Schirmer L, Igoillo-Esteve M, Santin I, Castellanos-Rubio A
An inflammation-associated lncRNA induces neuronal damage via mitochondrial dysfunction. Mol Ther Nucleic Acids; 2025 Jun 10; doi:10.1016/j.omtn.2025.102533 - Santhanam N, Kim HE, Rügamer D, Bender A, Muthers S, Cho CG, Alonso A, Szabo K, Centner FS, Wenz H, Ganslandt T, Platten M, Groden C, Neumaier M, Siegel F, Maros ME
Machine learning-based forecasting of daily acute ischemic stroke admissions using weather data. NPJ Digit Med; 2025 Apr 25; doi:10.1038/s41746-025-01619-w - González-Velasco O, Simon M, Yilmaz R, Parlato R, Weishaupt J, Imbusch CD, Brors B
Identifying similar populations across independent single cell studies without data integration. NAR Genom Bioinform; 2025 Jun; doi:10.1093/nargab/lqaf042 - Schubert KM, Zieglgänsberger D, Bicciato G, Abraira L, Santamarina E, Álvarez-Sabín J, Ferreira-Atuesta C, Katan M, Sinka L, Terziev R, Deligas N, Erdélyi-Canavese B, Felbecker A, Siebel P, Winklehner M, von Oertzen TJ, Wagner JN, Gigli GL, Nilo A, Janes F, Merlino G, Valente M, Zafra-Sierra MP, Mayor-Romero LC, Conrad J, Evers S, Alet M, Fukuma K, Ihara M, Landau B, Lochner P, Roell F, Brigo F, Bentes C, Peralta AR, Pinho E Melo T, Keezer MR, Duncan JS, Sander JW, Tettenborn B, Koepp MJ, Galovic M
Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality. Stroke; 2025 Jul; doi:10.1161/STROKEAHA.124.050045 - Dirven L, Machingura A, van den Bent MJ, Coens C, Bottomley A, Brandes AA, Domont J, Idbaih A, Koekkoek JAF, Reijneveld JC, Platten M, Wick W, Taphoorn MJB
Health-related quality of life in patients with progressive glioblastoma treated with combined bevacizumab and lomustine versus lomustine only: Secondary outcome of the randomized phase III EORTC 26101 study. Neurooncol Pract; 2025 Apr; doi:10.1093/nop/npae091 - Alonso A, Rogge A, Schramm P, Münch U, Jöbges S
[Recommendations for time-limited trial in neurocritical care]. Anaesthesiologie; 2025 Apr; doi:10.1007/s00101-025-01516-7 - Abu-Rumeileh S, Scholle L, Mensch A, Großkopf H, Ratti A, Kölsch A, Stoltenburg-Didinger G, Conrad J, De Gobbi A, Barba L, Steinacker P, Klafki HW, Oeckl P, Halbgebauer S, Stapf C, Posa A, Kendzierski T, Silani V, Hausner L, Ticozzi N, Froelich L, Weishaupt JH, Verde F, Otto M
Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis. Nat Commun; 2025 Mar 5; doi:10.1038/s41467-025-57144-7 - Lesch H, Haucke L, Kruska M, Ebert A, Becker L, Szabo K, Akin I, Alonso A, Fastner C
Myocardial injury in spontaneous intracerebral hemorrhage is not predicted by prior cardiac disease or neurological status: results from the Mannheim Stroke database. Front Neurol; 2025; doi:10.3389/fneur.2025.1510361 - Maier A, Kettemann D, Weyen U, Grehl T, Schulte PC, Steinbach R, Rödiger A, Weydt P, Petri S, Wolf J, Grosskreutz J, Koch JC, Weishaupt JH, Rosseau S, Norden J, Körtvélyessy P, Koch B, Holm T, Hildebrandt B, Schumann P, Walter B, Riitano A, Münch C, Meyer T, Spittel S
Provision, cough efficacy and treatment satisfaction of mechanical insufflation-exsufflation in a large multicenter cohort of patients with amyotrophic lateral sclerosis. Sci Rep; 2025 Mar 1; doi:10.1038/s41598-025-91692-8 - Szabo K, Obertacke U, Sandikci V, Ghanayem S, Alonso A, Rink JS, Marzina A, Platten M, Hoyer C
Mind the guideline gap: emergent CT in patients with epilepsy for trauma rule-out-A retrospective cohort study. Neurol Res Pract; 2025 Feb 24; doi:10.1186/s42466-025-00370-7 - Steinfurth L, Grehl T, Weyen U, Kettemann D, Steinbach R, Rödiger A, Grosskreutz J, Petri S, Boentert M, Weydt P, Bernsen S, Walter B, GüNTHER R, Lingor P, Koch JC, Baum P, Weishaupt JH, Dorst J, Koc Y, Cordts I, Vidovic M, Norden J, Schumann P, Körtvélyessy P, Spittel S, Münch C, Maier A, Meyer T
Self-assessment of amyotrophic lateral sclerosis functional rating scale on the patient's smartphone proves to be non-inferior to clinic data capture. Amyotroph Lateral Scler Frontotemporal Degener; 2025 Feb 22; doi:10.1080/21678421.2025.2468404 - Wischnewski S, Rausch HW, Ikenaga C, Leipe J, Lloyd TE, Schirmer L
Emerging mechanisms and therapeutics in inflammatory muscle diseases. Trends Pharmacol Sci; 2025 Mar; doi:10.1016/j.tips.2025.01.005 - Peng T, Ma X, Hua W, Wang C, Chu Y, Sun M, Fermi V, Hamelmann S, Lindner K, Shao C, Zaman J, Tian W, Zhuo Y, Harim Y, Stöffler N, Hammann L, Xiao Q, Jin X, Warta R, Lotsch C, Zhuang X, Feng Y, Fu M, Zhang X, Zhang J, Xu H, Qiu F, Xie L, Zhang Y, Zhu W, Du Z, Salgueiro L, Schneider M, Eichhorn F, Lefevre A, Pusch S, Grinevich V, Ratliff M, Loges S, Bunse L, Sahm F, Xiang Y, Unterberg A, von Deimling A, Platten M, Herold-Mende C, Wu Y, Liu HK, Mao Y
Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy. Cell Stem Cell; 2025 Apr 3; doi:10.1016/j.stem.2025.01.002 - Möhwald LM, Maier A, Grehl T, Weyen U, Weydt P, Günther R, Lingor P, Göricke B, Petri S, Grosskreutz J, Boentert M, Cordts I, Weishaupt JH, Dorst J, Münch C, Meyer T, Baum P
Shared prognostic information in amyotrophic lateral sclerosis - systematic assessment of the patients' perception of neurofilament light chain and the ALS functional rating scale. Neurol Res Pract; 2025 Feb 6; doi:10.1186/s42466-024-00363-y - Psychogios M, Brehm A, Ribo M, Rizzo F, Strbian D, Räty S, Arenillas JF, Martínez-Galdámez M, Hajdu SD, Michel P, Gralla J, Piechowiak EI, Kaiser DPO, Puetz V, Van den Bergh F, De Raedt S, Bellante F, Dusart A, Hellstern V, Khanafer A, Parrilla G, Morales A, Kirschke JS, Wunderlich S, Fiehler J, Thomalla G, Lemmens R, Peluso JP, Bolognese M, von Hessling A, van Es A, Kruyt ND, Coutinho JM, Castaño C, Minnerup J, van Zwam W, Dhondt E, Nolte CH, Machi P, Loehr C, Mattle HP, Buhk JH, Kaesmacher J, Dobrocky T, Papanagiotou P, Alonso A, Holtmannspoetter M, Zini A, Renieri L, Keil F, van den Wijngaard I, Kägi G, Terceño M, Wiesmann M, Amaro S, Rommers N, Balmer L, Fragata I, Katan M, Leker RR, Saver JL, Staals J, Fischer U, DISTAL Investigators
Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels. N Engl J Med; 2025 Apr 10; doi:10.1056/NEJMoa2408954 - Chih YC, Dietsch AC, Koopmann P, Ma X, Agardy DA, Zhao B, De Roia A, Kourtesakis A, Kilian M, Krämer C, Suwala AK, Stenzinger M, Boenig H, Blum A, Pienkowski VM, Aman K, Becker JP, Feldmann H, Bunse T, Harbottle R, Riemer AB, Liu HK, Etminan N, Sahm F, Ratliff M, Wick W, Platten M, Green EW, Bunse L
Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen. Nat Commun; 2025 Feb 1; doi:10.1038/s41467-025-56547-w - Diener HC, Kuklik N, Hüsing A, Alonso A, Nabavi DG, Poli S, Gabriel MM, Maier IL, Grans J
Andexanet alfa in patients with factor Xa inhibitor-associated intracranial hemorrhage: The prospective observational multicenter ASTRO-DE study. Int J Stroke; 2025 Feb 9; doi:10.1177/17474930251317385 - Thomann AK, Schmitgen MM, Stephan JC, Knoedler LL, Gass A, Thomann PA, Ebert MP, Reindl W, Wolf RC
Disease-State Dependent Associations Between Intrinsic Brain Function and Symptoms of Fatigue, Depression, and Anxiety in Crohn's Disease. Inflamm Bowel Dis; 2025 Jan 15; doi:10.1093/ibd/izae318 - Kruska M, Alonso A, Akin I, Fastner C
Intertwined destinies - Acute ischemic stroke and neurogenic stress cardiomyopathy. J Stroke Cerebrovasc Dis; 2025 Apr; doi:10.1016/j.jstrokecerebrovasdis.2024.108222 - Raghavan R, Friedrich MJ, King I, Chau-Duy-Tam Vo S, Strebinger D, Lash B, Kilian M, Platten M, Macrae RK, Song Y, Nivon L, Zhang F
Rational engineering of minimally immunogenic nucleases for gene therapy. Nat Commun; 2025 Jan 2; doi:10.1038/s41467-024-55522-1 - Kooistra SM, Schirmer L
Multiple Sclerosis: Glial Cell Diversity in Time and Space. Glia; 2025 Mar; doi:10.1002/glia.24655 - Kneihsl M, Hakim A, Goeldlin MB, Meinel TR, Branca M, Rohner R, Fenzl S, Abend S, Shim GC, Gumbinger C, Zhang L, Kristoffersen ES, Desfontaines P, Vanacker P, Alonso A, Poli S, Nunes AP, Caracciolo NG, Gattringer T, Kahles T, Giudici D, Demeestere J, Dawson J, Fischer U, ELAN investigators
Early vs Late Anticoagulation After Ischemic Stroke in Patients With Atrial Fibrillation and Covert Brain Infarcts. Neurology; 2025 Jan 14; doi:10.1212/WNL.0000000000210157 - Bonev B, Castelo-Branco G, Chen F, Codeluppi S, Corces MR, Fan J, Heiman M, Harris K, Inoue F, Kellis M, Levine A, Lotfollahi M, Luo C, Maynard KR, Nitzan M, Ramani V, Satijia R, Schirmer L, Shen Y, Sun N, Green GS, Theis F, Wang X, Welch JD, Gokce O, Konopka G, Liddelow S, Macosko E, Ali Bayraktar O, Habib N, Nowakowski TJ
Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery. Nat Neurosci; 2025 Jan; doi:10.1038/s41593-024-01858-2 - Uchiyama S, Hoshino T, Minematsu K, Meledje ML, Charles H, Albers GW, Caplan LR, Donnan GA, Ferro JM, Hennerici MG, Molina C, Rothwell PM, Wong LK, Amarenco P
Risk of major vascular events in patients without traditional risk factors after transient ischemic attack or minor ischemic stroke: An international prospective cohort. Eur Stroke J; 2025 Jun; doi:10.1177/23969873241300071 - Tabatabai G, Platten M, Preusser M, Weller M, Wick W, van den Bent M
Treatment of glioblastoma patients with personalized vaccines outside clinical trials: Lessons ignored? Neuro Oncol; 2025 Jan 12; doi:10.1093/neuonc/noae225 - Rink JS, Szabo K, Hoyer C, Saver JL, Nour M, Audebert HJ, Kunz WG, Froelich MF, Heinzl A, Tschalzev A, Hoffmann J, Schoenberg SO, Tollens F
Mobile stroke units services in Germany: A cost-effectiveness modeling perspective on catchment zones, operating modes, and staffing. Eur J Neurol; 2025 Jan; doi:10.1111/ene.16514 - Mrochen A, Alhaj Omar O, Pelz JO, Michalski D, Neugebauer H, Lehrieder D, Knier B, Ringmaier C, Stetefeld H, Schönenberger S, Chen M, Schneider H, Alonso A, Lesch H, Totzeck A, Erdlenbruch F, Hiller B, Diel NJ, Worm A, Claudi C, Gerner ST, Huttner HB, Schramm P
Guideline-recommended basic parameter adherence in neurocritical care stroke patients: Observational multicenter individual participant data analysis. Eur Stroke J; 2025 Jun; doi:10.1177/23969873241289360 - Meyer T, Schumann P, Grehl T, Weyen U, Petri S, Rödiger A, Steinbach R, Grosskreutz J, Bernsen S, Weydt P, Wolf J, Günther R, Vidovic M, Baum P, Metelmann M, Weishaupt JH, Streubel B, Kasper DC, Koc Y, Kettemann D, Norden J, Schmitt P, Walter B, Münch C, Spittel S, Maier A, Körtvélyessy P
SOD1 gene screening in ALS - frequency of mutations, patients' attitudes to genetic information and transition to tofersen treatment in a multi-center program. Amyotroph Lateral Scler Frontotemporal Degener; 2025 Feb; doi:10.1080/21678421.2024.2401131 - Zylla MM, Özdemir B, Hochadel M, Zeymer U, Akin I, Grau A, Schneider S, Alonso A, Waldecker B, Süselbeck T, Schwacke H, Haass M, Zahn R, Borggrefe M, Senges J, Frey N, Thomas D
Community-based analysis of stroke prevention and effect of public interventions in atrial fibrillation: results from the ARENA project. Clin Res Cardiol; 2025 Jan; doi:10.1007/s00392-024-02510-6 - Tan CL, Lindner K, Boschert T, Meng Z, Rodriguez Ehrenfried A, De Roia A, Haltenhof G, Faenza A, Imperatore F, Bunse L, Lindner JM, Harbottle RP, Ratliff M, Offringa R, Poschke I, Platten M, Green EW
Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy. Nat Biotechnol; 2025 Jan; doi:10.1038/s41587-024-02161-y